I would NOT suggest to give it a tranquilizer or sedative. Because the horse will never get used to the noise and it will just be agitated every time. But I would suggest to do your ground work or lunge your horse while making that noise to let the horse know that its just another work out, so its a normal noise. It would be easier to just start off working the horse with the noise afar off then increase the noise closer to get the horse used to it. I hope this helps because it helped me.