I personally never saw much improvement from oral joint supplements. Obviously many do (or think they do… beware of placebo effect!), but personally I would rather spend my money on researched and proven drugs. If your vet will write a script for it, Pentosan (can be purchased from Wedgewood) is an IM injectable drug for joints/arthritis and many, many people have had great luck with it on COTH. Adequan is another option. Previcox is easier on the GI tract than bute and Previcox is cheaper than many oral joint supps if you get the larger pill and break it in quarters. It is not without risk but is better on their stomachs than bute if that is a concern. Joint injections are another option. So many alternatives to daily bute!